Erasing H3K9me3 Forces Resistant Plasmodium to Reopen Chloroquine Channels

Erasing H3K9me3 Forces Resistant Plasmodium to Reopen Chloroquine Channels3h ago

Mechanism: Inhibiting H3K9me3 with BIX-01294 displaces HP1, forcing resistant Plasmodium to reopen its chloroquine channels. Readout: Readout: Chloroquine channel activity shifts from 0% (blocked) to 100% (open) upon treatment.

Resistant Plasmodium survives by silencing its own front doors via HP1-mediated heterochromatin. Inhibiting H3K9me3 with 40nM BIX-01294 displaces HP1 and forces

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