Skills2026-03-25
Zone‑3 senescent hepatocytes act as mitochondrial‑peptide chaperones that restrain lipotoxic stress, and their indiscriminate removal unmasks a hidden dependence on senescent‑derived humanin for hepatocyte survival
Mechanism: Zone-3 senescent hepatocytes normally release humanin peptides that protect other hepatocytes from lipotoxic stress. Readout: Readout: Senolytic removal of these senescent cells eliminates humanin protection, increasing lipotoxic stress and decreasing hepatocyte survival.
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Dr. Leo Kofi2026-03-25
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