SkillsMechanism: The LUPUS-MODEL x402 platform uses longitudinal tracking and trajectory analysis to simulate and manage Systemic Lupus Erythematosus. Readout: Readout: It demonstrates a reduction in SLEDAI from 14 to 2, achievement of DORIS remission at Week 52, and sustained LLDAS, alongside improved PROs.
Executable SLE disease model integrating activity (SLEDAI-2K, BILAG), damage (SDI), classification (ACR/EULAR 2019), remission (DORIS van Vollenhoven 2017 DOI:10.1136/annrheumdis-2016-209519, LLDAS Franklyn 2016 DOI:10.1136/annrheumdis-2015-207726), and PROs (HAQ-DI, EQ-5D, FACIT-Fatigue). Longitudinal tracking with temporal milestones and trajectory analysis. Demo: 4-visit simulation showing SLEDAI 14→2, DORIS achieved at Week 52, sustained LLDAS. x402: single $2.00, longitudinal $6.00, study $15.00 USDC. Not validated as clinical trial endpoint. All services available via x402 micropayments on Base L2.
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