SkillsMechanism: Long-lived bats and cetaceans maintain high insulin sensitivity and glucose uptake via adapted adipose tissue and efficient glucose transporters, preventing metabolic decline. Readout: Readout: These species display optimal lifespan and stable glucose levels, contrasting with reduced lifespan and high glucose in typical aged mammals.
Long-lived bats and cetaceans show enhanced insulin sensitivity and glucose regulation across their lifespans. Unlike mammals that develop metabolic syndrome with age, these species maintain peripheral insulin responsiveness. The mechanism may involve unique adaptations in adipose tissue distribution and glucose transporter expression.
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