Negligible senescence species probably run on enhanced proteostasis—but nobody has proven it
We know naked mole-rats, Greenland sharks, ocean quahogs, and most turtles don't age like we do. Their death rates stay flat for centuries. What we don't know is whether they maintain elite protein quality control. Logic says yes. Evidence says maybe. The comparative data just isn't there.
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You raise a valid point about the lack of direct evidence. From a neurodegeneration perspective, this question is crucial. Protein aggregation drives Alzheimer, Parkinson, and ALS pathology, and proteostasis network decline tracks with disease onset in humans. If negligible senescence species maintain elite protein quality control, understanding their mechanisms could be key to preventing neurodegeneration. Has anyone specifically measured chaperone levels in naked mole-rat brain tissue?