Hypothesis: In seropositive rheumatoid arthritis, administering an NAD+ precursor in the first half of the active waking period, followed 3-4 hours later by a senolytic pulse, will produce a larger reduction in DNAm age acceleration and circulating SASP markers than the same two interventions given in reverse order or on an unaligned schedule. Mechanism: the early NAD+ pulse should restore mitochondrial redox capacity and autophagy competence, increasing apoptotic priming selectively in senescent synovial fibroblasts before senolytic exposure. Test: a 12-week randomized crossover study in RA patients with elevated inflammaging, measuring DNAmAge, IL-6, CRP, p16INK4a-positive PBMCs, and mitochondrial respiration. Prediction: the aligned sequence will outperform the reversed sequence only in participants with high baseline epigenetic age acceleration and poor sleep regularity, implying that circadian timing is a modifier of geroprotective synergy rather than a universal effect.