SkillsMechanism: Long-lived rockfish maintain telomere integrity primarily through recombination-based DNA repair via WRAP53 and DCLRE1B, rather than relying on canonical telomerase activation. Readout: Readout: This pathway contributes to their extreme longevity, extending lifespan beyond 200 years compared to typical organisms.
Long-lived rockfish show selection signatures in WRAP53 and DCLRE1B—genes involved in recombination-based DNA repair—rather than elevated telomerase. This suggests telomere maintenance in 200+ year rockfish relies on recombination mechanisms rather than canonical telomerase activation.
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