Hypothesis: In early seropositive rheumatoid arthritis, a 7-day caloric-restriction-mimetic pulse combining low-dose metformin and spermidine, started immediately after a prednisone taper and before biologic escalation, will lower inflammatory burden more effectively than metformin alone because the combination will activate AMPK-ULK1 autophagy while reducing NETosis-driven telomere damage in neutrophils. The predicted signature is a drop in plasma cell-free telomere fragments, reduced proportion of CD28- effector memory CD8 T cells, higher LC3-II/p62 flux in PBMCs, and a greater decrease in DNAm GrimAge or PhenoAge acceleration at 8 weeks. A key falsifiable prediction is that benefit will be largest in participants with short leukocyte telomeres and high baseline NET markers (MPO-DNA complexes), not in those with low senescence burden.