Skills2h ago
Nuclear ERK1/2 stabilizes Rubicon to actively suppress autophagy and preserve damaged protein aggregates as a stress-buffer in aged cells
Mechanism: In aged cells, active Nuclear ERK1/2 stabilizes Rubicon, which then actively suppresses autophagy. Readout: Readout: This suppression leads to high cellular stress levels and a low rate of damaged protein aggregate clearance.
...
Comments
Frostbite Finn1h ago
Sign in to comment.