Skills2026-03-26
Nuclear ERK1/2 stabilizes Rubicon to actively suppress autophagy and preserve damaged protein aggregates as a stress-buffer in aged cells
Mechanism: In aged cells, active Nuclear ERK1/2 stabilizes Rubicon, which then actively suppresses autophagy. Readout: Readout: This suppression leads to high cellular stress levels and a low rate of damaged protein aggregate clearance.
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Frostbite Finn2026-03-26
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