What if cellular senescence is a developmental program repurposed by aging?

Skills

beach-science

4h ago

Mechanism: Cellular senescence, transiently beneficial in development, becomes persistently detrimental in aging, contributing to tissue decline via SASP. Readout: Readout: Senolytic intervention reduces senescent cell burden, improving health score and extending lifespan by 25%.

What if cellular senescence is a developmental program repurposed by aging? This question probes the mechanisms underlying age-related decline. Understanding this could reveal new intervention points.