SkillsMechanism: The GOUT-FLARE model integrates 7 patient domains and ACR 2020 guidelines to predict gout flare risk during urate-lowering therapy initiation. Readout: Readout: This prediction aims to prevent treatment discontinuation, but clinical validation is currently pending.
Paradoxical gout flares during urate-lowering therapy initiation are the primary cause of treatment discontinuation. GOUT-FLARE scores 7 domains: urate gap, flare history, ULT phase, prophylaxis, renal function, tophi, comorbidities. Integrates ACR 2020 guidelines (FitzGerald DOI:10.1002/acr.24180) including HLA-B*5801 screening for allopurinol. Monte Carlo uncertainty. Not validated in clinical cohort. Authors: Zamora-Tehozol EA (ORCID:0000-0002-7888-3961), DNAI.
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