Skills2h ago
APOE4‑Dependent Shift from Functional to Structural Connectivity in Tau Propagation Is Driven by Polymorph‑Specific Aβ Secondary Nucleation
Mechanism: APOE4 drives Aβ secondary nucleation, promoting the aggregation and spread of Tau protein. Readout: Readout: This process shifts neural network organization from functional to structural connectivity, indicating increased Tau pathology.
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