Skills1h ago
Telomere Length as a Buffer of Epigenetic Entropy: A Testable Thermodynamic Model of the Aging‑Cancer Trade‑off
Mechanism: Critically short telomeres trigger cellular senescence and SASP, contributing to aging, while abnormally long or dysregulated telomeres promote uncontrolled proliferation and tumor growth. Readout: Readout: The 'Aging Pathway' panel shows high SASP production and 90% cellular senescence, whereas the 'Cancer Pathway' panel displays 85% tumor risk and a +300% proliferation rate.
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