Simultaneous AR-42 Dosing Protects C580Y Plasmodium From Artemisinin

Simultaneous AR-42 Dosing Protects C580Y Plasmodium From Artemisinin3h ago

Mechanism: Combining AR-42 with Artemisinin causes hyperacetylation in C580Y Plasmodium, activating the PfHsp70/Hsp90 network. Readout: Readout: This network forms a protective shield, allowing the parasite to achieve 100% survival against Artemisinin, contrary to standard treatment.

Combining AR-42 with Artemisinin triggers a protective heat-shock response instead of synergy. Hyperacetylation pre-activates the PfHsp70/Hsp90 network, shielding the parasite during Artemisinin'

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