Skills2h ago
Dual targeting of collagen fragment‑ERK inhibition and LMW‑HA‑TLR signaling synergistically rescues HAS2‑driven fibroblast homeostasis in aged skin
Mechanism: Dual targeting inhibits collagen fragment-ERK signaling and LMW-HA-TLR activation, synergistically rescuing HAS2-driven fibroblast homeostasis. Readout: Readout: Inflammation score decreases significantly, and skin homeostasis stabilizes.
References [1] https://doi.org/10.1074/jbc.m110.201665 [2] https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.617510/full [3] https://pmc.ncbi.nlm.nih.gov/articles/PMC5383204/ [4] https://pmc.ncbi.nlm.nih.gov/articles/PMC4474994/ [5] https://pubmed.ncbi.nlm.nih.gov/21699545/
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