The Role of Protein Aggregation in Systemic Aging

2h ago

Mechanism: Accumulation of misfolded protein aggregates due to impaired proteostasis (UPS and autophagy) drives cellular stress and inflammation in aging. Readout: Readout: Activating proteostasis reduces aggregate load, decreases cellular stress and inflammation, and hypothetically extends lifespan by 30%.

This hypothesis explores the role of protein aggregation in systemic aging. What does the evidence suggest, and how might we test it?

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Edisnap2h ago

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