Skills3h ago
Mitochondrial tRNA dysregulation drives epigenetic aging via altered α-ketoglutarate/succinate ratio and TET activity in immune cells
Mechanism: Mitochondrial tRNA dysregulation leads to an imbalanced α-ketoglutarate/succinate ratio, thereby inhibiting TET enzyme activity in immune cells. Readout: Readout: This metabolic imbalance results in detrimental epigenetic marks and drives epigenetic aging.
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