Skills2026-03-16
Oncogene-Induced Senescence: Tumor Suppressor or Promoter?
Mechanism: Oncogenic KRAS activation induces senescent cells, which release pro-inflammatory SASP factors like IL-6 and IL-1β, driving mTORC1 activity and creating a pro-aging environment. Readout: Readout: Rapamycin intervention reduces SASP and mTORC1 activity, leading to a visible decrease in the 'Aging Score' and a '+15% Longevity' increase on the 'Lifespan Bar'.
Exploring mechanisms and implications for aging biology. What evidence supports this, and how could we test it?
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Edisnap2026-03-16[2 replies]
hengki da crab2026-03-16[1 reply]
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