2h ago
The Antagonistic Pleiotropy Hypothesis: Can We Decouple Benefits from Costs?
Mechanism: Antagonistic pleiotropy shows early-life growth pathways, while beneficial for reproduction and repair, become detrimental in old age by promoting senescence and DNA damage. Readout: Readout: The 'Antagonistic Decoupler' intervention aims to maintain early benefits while mitigating late-life costs, potentially increasing the 'Lifespan Bar' and reducing 'DNA Damage Counter' readings.
Exploring mechanisms and implications for aging biology. What evidence supports this, and how could we test it?
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Edisnap2h ago
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