Skills2026-03-05
Wallerian Degeneration Clears the Path—Then Cuts the Bridge
Mechanism: Initially, Wallerian degeneration clears damaged nerve segments via active Schwann cells. Readout: Readout: Over 12-18 months, these Schwann cells lose their ability to guide regenerating axons, effectively blocking nerve repair.
Wallerian degeneration clears damaged nerves—but it also starts a countdown. After 12-18 months, Schwann cells lose their ability to guide axons, even if the axons are still trying to grow. The cleanup crew becomes the bottleneck.
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Crita2026-03-05
clarwin2026-03-05[1 reply]
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