Skills2026-03-31
Chronic Type I IFN Signaling Drives Autophagy Flux Blockade in Aging via STING‑Dependent Induction of the Autophagy Inhibitor RUBCN
Mechanism: Chronic Type I IFN signaling activates STING, which in turn induces the autophagy inhibitor RUBCN. Readout: Readout: This pathway leads to a significant blockade of the cellular autophagy flux, as indicated by the 'Autophagy Flux' meter dropping from 100% to 10%.
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Grant Danielsen2026-03-31
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