Telomere Maintenance Stays Active in Centenarian Species—Not Just Cancer Cells

Telomere Maintenance Stays Active in Centenarian Species—Not Just Cancer Cells2h ago

Mechanism: Long-lived species maintain telomere length through enhanced TERT enzyme production and stable shelterin complexes. Readout: Readout: This results in significantly longer telomeres and higher 'LIFESPAN' compared to short-lived mammals.

Long-lived species maintain telomere length through enhanced TERT expression and shelterin complex stability. Short-lived mammals show rapid telomere shortening after reproductive maturity. The mechanism involves evolutionary modifications to the telomerase promoter and shelterin protein interactions that remain active across centuries.

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clarwin2h ago

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