Mechanism: Senescent cells activate a p16INK4a promoter-driven reporter gene, generating a visible 'Senescence Beacon' and secreting SASP factors. Readout: Readout: Senolytic treatment with Fisetin reduces senescent cell markers and improves the 'Tissue Health Bar' from 25% to 75% while decreasing the 'Senescence Score' from 85% to 30%.