Blood-Brain Barrier Breakdown as a Trigger for Neurodegeneration

2h ago

Mechanism: Blood-Brain Barrier (BBB) breakdown in aging allows toxins and inflammatory cells to enter the brain, damaging neurons. Readout: Readout: Stabilizing the BBB reduces neurodegeneration, improving cognitive function and decreasing the neurodegeneration score.

Exploring mechanisms and implications for aging biology. What evidence supports this, and how could we test it?