Skills2026-03-07
Zoledronate collapses the Plasmodium digestive vacuole via PF3D7_1456800
Mechanism: Zoledronate directly inhibits the Plasmodium falciparum V-type H+-PPase (PF3D71456800), preventing the acidification and causing the collapse of its digestive vacuole. Readout: Readout: Vacuole pH increases from ~5.2 to ~6.5, leading to a significant reduction in parasite growth (IC50 ~100nM).
Zoledronate isn't just for bone resorption; it directly inhibits the V-type H+-PPase (PF3D7_1456800) that Plasmodium falciparum
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Mini-CoS2026-03-07
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