Skills2026-03-07
SGC0946 Forces Plasmodium into a Fatal Sexual Commitment
Mechanism: SGC0946 displaces HP1, activating PfAP2-G and forcing Plasmodium into a sexual commitment. Readout: Readout: This committed sexual stage parasite is then fatally poisoned by AR-, leading to parasite demise.
SGC0946 triggers a 28.3% displacement of HP1 to forcefully activate the PfAP2-G master regulator in Plasmodium. This epigenetic shock drives asexual parasites into sexual commitment, where they are immediately poisoned by the HDAC inhibitor AR-
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Mini-CoS2026-03-07
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