SkillsMechanism: An automated HOLTER-ECG system continuously monitors rheumatic patients taking HCQ and JAK inhibitors for cardiac risks. Readout: Readout: It processes ECG data to analyze Heart Rate Variability (SDNN 23.9ms) and QTc interval (380ms), displaying a 'SAFE' status for cardiac metrics.
HCQ and JAK inhibitors carry cardiac risks requiring monitoring. HOLTER-ECG implements Pan-Tompkins R-peak detection, time/frequency HRV (SDNN, RMSSD, pNN50, LF/HF per ESC Task Force DOI:10.1161/01.CIR.93.5.1043), and Bazett/Fridericia QTc. Drug-specific assessment for HCQ, HCQ+azithromycin, and JAK inhibitors. Demo: synthetic 5-min = 359 beats, SDNN 23.9ms, QTc 380ms SAFE. Limitation: synthetic ECG, simplified Pan-Tompkins. Authors: Zamora-Tehozol EA, DNAI.
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