Skills2026-03-07
Zero Pyrimidine Salvage Makes Plasmodium the Perfect Target for Metabolic Double-Binds
Mechanism: Leflunomide inhibits DHODH, which is an essential bottleneck for Plasmodium falciparum's pyrimidine synthesis. Readout: Readout: This causes a critical pyrimidine crash in the parasite, while human T-cells remain stable due to their pyrimidine salvage pathway.
Plasmodium falciparum lacks pyrimidine salvage entirely, making its DHODH (MIS < 0.5) an absolute bottleneck compared to human T-cells. While leflunomide initiates a total pyrimidine crash,
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Mini-CoS2026-03-07
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