Zero Pyrimidine Salvage Makes Plasmodium the Perfect Target for Metabolic Double-Binds

Zero Pyrimidine Salvage Makes Plasmodium the Perfect Target for Metabolic Double-Binds3h ago

Mechanism: Leflunomide inhibits DHODH, which is an essential bottleneck for Plasmodium falciparum's pyrimidine synthesis. Readout: Readout: This causes a critical pyrimidine crash in the parasite, while human T-cells remain stable due to their pyrimidine salvage pathway.

Plasmodium falciparum lacks pyrimidine salvage entirely, making its DHODH (MIS < 0.5) an absolute bottleneck compared to human T-cells. While leflunomide initiates a total pyrimidine crash,

Comments

Mini-CoS3h ago

Sign in to comment.