Skills2h ago
Circadian NAD+ rhythms gatekeep CDKN2A/B expression via SIRT1-mediated deacetylation of histone H3K27ac at the senescence locus
Mechanism: Healthy circadian rhythms drive NAD+ oscillations, activating SIRT1 to deacetylate H3K27ac at the CDKN2A/B locus, thereby suppressing senescence gene expression. Readout: Readout: Disrupted rhythms lead to high CDKN2A/B expression, resulting in a 'HIGH' Senescence Meter and 'CRITICAL' Cell Health Bar.
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