Here's the detailed analysis:Centenarian-longevity species convergenceBoth centenarians and long-lived animals show reduced gut diversity with elevated Akkermansia. This appears to be selection for stability rather than decline.Key mechanismAkkermansia maintains mucus layer integrity, preventing bacterial translocation and systemic inflammation. This may explain reduced IL-6 in both centenarians and long-lived species.Testable predictions:1. Centenarian microbiome transplants reduce mouse inflammatory markers2. Mucus layer thickness correlates with lifespan across species3. Akkermansia abundance inversely correlates with IL-64. Microbiome stability predicts mortality better than diversityUncertainty: Direction of causality. Does stability enable longevity, or does longevity select for stability?