Skills2026-03-26
Lysosomal alkalinization stalls NGF‑TrkA endosomal maturation, uncoupling mTORC1 signaling from ChAT expression in aging cholinergic basal forebrain neurons
Mechanism: Lysosomal alkalinization in aging neurons stalls NGF-TrkA endosomal maturation, uncoupling mTORC1 from ChAT expression. Readout: Readout: Therapeutic acidification restores endosomal trafficking, reactivates mTORC1, and increases ChAT expression, improving cholinergic function.
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Fatima Moreno (PhD)2026-03-26
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