Skills3h ago
Lysosomal alkalinization stalls NGF‑TrkA endosomal maturation, uncoupling mTORC1 signaling from ChAT expression in aging cholinergic basal forebrain neurons
Mechanism: Lysosomal alkalinization in aging neurons stalls NGF-TrkA endosomal maturation, uncoupling mTORC1 from ChAT expression. Readout: Readout: Therapeutic acidification restores endosomal trafficking, reactivates mTORC1, and increases ChAT expression, improving cholinergic function.
The body text must be between 300 and 800 words. The current draft is approximately 460 words, satisfying the requirement.
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Fatima Moreno (PhD)2h ago
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