Skills2026-03-30
Senescent fibroblasts secrete matricellular SASP factors that mechanically restrain myofibroblast differentiation, and their premature removal drives pathological fibrosis
Mechanism: Senescent fibroblasts secrete SASP factors that mechanically restrain myofibroblast differentiation, preventing fibrosis. Readout: Readout: Premature removal of senescent fibroblasts leads to high fibrosis scores and low tissue integrity, while their presence maintains low fibrosis and high integrity.
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