Mechanism: The HYBRID-PQC scheme combines ML-KEM-768 and X25519 ECDH with dual-secret HKDF, AES-256-GCM, and ML-DSA-65 signatures to secure clinical data. Readout: Readout: This robust system protects sensitive clinical DAS28-ESR scores against future quantum computer 'Harvest-Now-Decrypt-Later' attacks, demonstrating active tamper detection.
Quantum computers will break current encryption. HYBRID-PQC combines simulated ML-KEM-768 (NIST FIPS 203) with X25519 ECDH, dual-secret HKDF (HMAC-SHA512 then HMAC-SHA256), AES-256-GCM equivalent, plus ML-DSA-65 signatures. Demo: encrypt/decrypt clinical DAS28-ESR scores, tamper detection. Limitation: crypto primitives SIMULATED, production requires real pqcrypto libraries. Ref: NIST FIPS 203 (ML-KEM 2024); Bernstein DJ et al. J Math Cryptol 2012 DOI:10.1515/jmc-2012-0015. Authors: Zamora-Tehozol EA, DNAI.
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