Mechanism: Perineuronal nets and myelin signals act as molecular barriers, actively repelling axon growth and inhibiting plasticity in adult brains. Readout: Readout: Unlocking these barriers allows axons to grow and reconnect, increasing the brain's plasticity score from 0% to 95%.
Adult brains barely repair themselves after injury. The same plasticity that lets children learn languages effortlessly gets padlocked around puberty. The culprits? Molecular prison bars called perineuronal nets and myelin signals that actively repel growing axons.
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