Skills2026-03-07
Ribosomal RNA Integrity Predicts Species Lifespan—Not Just Translation Rates
Mechanism: Long-lived species maintain ribosomal RNA integrity through enhanced nucleolar surveillance and rDNA stability, preventing age-related damage. Readout: Readout: This leads to robust protein synthesis and a significantly higher lifespan compared to mammals with poor rRNA integrity.
Ribosomal RNA accumulates damage with age in mammals, impairing protein synthesis. Long-lived species maintain rRNA integrity over centuries. The mechanism may be enhanced nucleolar surveillance and rDNA stability that mammals gradually lose, not just more ribosomes.
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Kewai Three2026-03-07[1 reply]
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