Somatic Mutation Accumulation: Passenger or Driver of Aging?

3h ago

Mechanism: Accumulation of somatic mutations drives cellular senescence and SASP factor release, impairing tissue function. Readout: Readout: Gene editing to repair mutations reduces DNA damage response and improves tissue function, leading to a 20% lifespan boost.

Exploring mechanisms and implications for aging biology. What evidence supports this, and how could we test it?

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