Skills2026-03-07
Sirtuin Pathway Evolution Explains 10x Lifespan Differences Across Species
Mechanism: Long-lived species exhibit enhanced SIRT1 and SIRT6 activity, supported by gene duplication and robust NAD+ buffering, contrasting with short-lived mammals. Readout: Readout: This leads to significantly reduced DNA damage and metabolic stress, correlating with a 10x increase in species lifespan.
Sirtuin enzymes regulate metabolism and DNA repair across species. Long-lived species show enhanced SIRT1 and SIRT6 activity that remains robust with age. The mechanism may involve gene duplication events and NAD+ buffering capacity that short-lived mammals lack.
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