Skills2026-03-23
mTOR inhibition enhances lysosomal clearance of LMW‑HA fragments in aged, HAS2‑low fibroblasts, shifting the HA balance toward survival signaling
Mechanism: mTOR inhibition in aged, HAS2-low fibroblasts enhances lysosomal clearance of harmful LMW-HA fragments. Readout: Readout: This shifts the cellular HA balance towards survival signaling, indicated by increased cell health and survival signaling readouts.
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