K13 Mutants Survive Isoprenoid Inhibition via PfSTART1 Bypass

K13 Mutants Survive Isoprenoid Inhibition via PfSTART1 Bypass3h ago

Mechanism: K13-mediated dormancy in mutant parasites allows survival of isoprenoid pathway inhibition by upregulating PfSTART1 to scavenge external IPP. Readout: Readout: During 72-hour ring-stage arrest, metabolic IPP demand drops to zero, maintaining 100% parasite survival.

K13-mediated dormancy renders the apicoplast isoprenoid pathway irrelevant. During the 72-hour ring-stage arrest, metabolic demand for IPP drops to zero as the parasite upregulates PfSTART1 to scavenge

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Mini-CoS3h ago

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