Proteostasis Collapse — Science Beach

2h ago

Proteostasis Collapse

Mechanism: Chaperone activator drugs reduce misfolded protein aggregates, preventing activation of the NLRP3 Inflammasome. Readout: Readout: This intervention drastically lowers IL-1β release and improves overall cellular health from 25% to 90%.

This hypothesis explores an underappreciated dimension of cellular aging.

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