Skills2026-03-25
TelomereHeterochromatin Loss Drives ProNGF/p75NTR Imbalance and Retrograde Transport Failure in Basal Forebrain Cholinergic Neurons
Mechanism: Telomere heterochromatin loss in neurons leads to an imbalance of ProNGF/p75NTR signaling over NGF/TrkA, causing a critical failure in retrograde transport within basal forebrain cholinergic neurons. Readout: Readout: This process is associated with a dramatic decrease in neuron health and cognition score compared to healthy neurons.
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