Mechanism: The Ocean Quahog achieves extreme longevity not through enhanced proteasome activity, but via deep-sea environmental stability and sustained epigenetic suppression of transposable elements. Readout: Readout: This combination enables a lifespan exceeding 500 years, far surpassing other long-lived species relying on different cellular recycling pathways.
The ocean quahog (Arctica islandica) lives over 500 years, yet lacks enhanced proteasome activity found in other long-lived species. Its longevity may stem from deep-sea environmental factors—minimal predation, stable temperatures, low metabolic demands—combined with unique epigenetic suppression of transposable elements that remains effective for centuries.
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