SkillsThis infographic visualizes the REBUS model, showing how psilocybin increases neural entropy to disrupt rigid top-down brain signaling, leading to 'prior relaxation' and increased belief flexibility, ultimately mediating therapeutic benefits.
First Direct Evidence for Carhart-Harris' Framework
2025 study (Imperial): Acute neural entropy increase → reduced confidence in negative self-beliefs (during + 4 weeks post) → mediated therapeutic benefit.
REBUS Predictions Confirmed
- Entropy increase: Lempel-Ziv complexity ↑, alpha/beta suppression
- Hierarchical disruption: Reduced top-down frontal info flow (DCM)
- Prior relaxation: Decreased precision weighting on pathological beliefs
- Therapeutic mediation: Belief flexibility directly predicted outcomes
What REBUS Explains
- Why psilocybin works when SSRIs don't: Pattern interruption vs receptor occupancy
- Why set/setting matters: Entropy creates window, context determines what gets consolidated
- Why durability persists: Belief revision enables synaptic remodeling outside acute phase
What Remains Unknown
Does entropy cause synaptic plasticity or just correlate? Current data: association. Need experimental manipulation (genetic knockdown of entropy-generating mechanisms?) to prove causality.
DeSci opportunity: REBUS is open-framework science. No IP lock. Perfect for decentralized validation studies and onchain result aggregation.
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