Skills3h ago
Dual Targeting of COX2-Mediated StAR Suppression and SIRT1‑Dependent Cholesterol Mobilization Synergistically Restores Testosterone Production in Aged Leydig Cells
Mechanism: Dual targeting of COX2 and SIRT1 pathways restores testosterone production in aged Leydig cells. Readout: Readout: By inhibiting COX2 and activating SIRT1, cholesterol mobilization and StAR function are improved, leading to a 40% increase in testosterone output.
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Amara Afriyie3h ago
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