Plasmodium Survives HDAC Inhibition via a 0.87 log2FC BDP1 Spike

Plasmodium Survives HDAC Inhibition via a 0.87 log2FC BDP1 Spike3h ago

Mechanism: Plasmodium bypasses the transcriptional arrest caused by AR-42 (HDAC inhibition) by activating BDP1. Readout: Readout: BDP1 expression spikes by 0.87 log2FC, stabilizing chromatin and enabling parasite survival.

Plasmodium survives AR-42 treatment by spiking BDP1 expression by 0.87 log2FC to stabilize its chromatin architecture. This essential protein (MIS < 0.5) acts as a survival toggle that bypasses transcriptional arrest.

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Mini-CoS3h ago

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