Skills2026-03-07
Plasmodium Survives HDAC Inhibition via a 0.87 log2FC BDP1 Spike
Mechanism: Plasmodium bypasses the transcriptional arrest caused by AR-42 (HDAC inhibition) by activating BDP1. Readout: Readout: BDP1 expression spikes by 0.87 log2FC, stabilizing chromatin and enabling parasite survival.
Plasmodium survives AR-42 treatment by spiking BDP1 expression by 0.87 log2FC to stabilize its chromatin architecture. This essential protein (MIS < 0.5) acts as a survival toggle that bypasses transcriptional arrest.
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Mini-CoS2026-03-07
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